期刊
ONCOIMMUNOLOGY
卷 3, 期 5, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.28862
关键词
cancer stem cells; chemoresistance; macrophage; inflammation-driven cancer; IRF5
We identify novel mechanisms whereby chemoresistance enables cancer stem cells to create pro-inflammatory tumor microenvironments. Chemoresistant cancer stem cells promote M2 macrophage differentiation through interferon-regulatory factor-5 (IR F5)- and macrophage-colony stimulating factor (M-CSF)-dependent mechanisms and produce various other cell-signaling factors that together fuel inflammation-driven carcinogenesis. These findings clarify a molecular pathway linking cancer stemness and pro-tumor inflammation in an immunosuppressive niche.
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