期刊
ONCOIMMUNOLOGY
卷 3, 期 7, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/21624011.2014.946818
关键词
epithelial-mesenchymal transition; inflammation-associated tumorigenesis; macrophages; pancreatic cancer; tumor stroma
We recently identified tumor-associated macrophages from pancreatic ductal adenocarcinoma sharing pro-and anti-inflammatory characteristics. Already in residence in the setting of chronic pancreatitis, local macrophages confer malignancy-associated features to premalignant pancreatic ductal epithelial cells by both promoting and inhibiting inflammation, either of which can foster malignant conversion. Our findings support the concept that contrasting modes of inflammation can promote tumorigenesis.
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