期刊
ONCOIMMUNOLOGY
卷 2, 期 5, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.24169
关键词
cancer stem cells; CD44; niche; osteopontin; tumor-associated macrophages
The reciprocal interaction between cancer stem cells and their niche is important for oncogenesis and tumor progression, but the factors involved in this interrelationship remain largely unknown. We have recently demonstrated that osteopontin plays a crucial role in the crosstalk between CD44(+) colorectal cancer stem cells and tumor-associated macrophages.
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