期刊
ONCOIMMUNOLOGY
卷 2, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.22841
关键词
antitumor immune responses; CD5; T cells; tumor-infiltrating T lymphocytes
资金
- Inserm
- Association pour la Recherche sur le Cancer (ARC)
- Ligue Nationale contre le Cancer
- Institut National contre le Cancer (INCa)
The destruction of tumor cells by the immune system is under the control of positive and negative receptors that tightly regulate T-cell effector functions. The T-cell receptor (TCR) inhibitory molecule CD5 critically contributes to the regulation of antitumor immune responses. Indeed, the modulation of CD5 within the tumor microenvironment corresponds to a strategy adopted by tumor-specific cytotoxic T lymphocytes (CTLs) to optimize their cytotoxic and cytokine secretion functions. In this review, we provide insights into the immunobiology of CD5 and its role in regulating antitumor CD8 T-cell responses, and suggest the possibility of targeting CD5 to improve the efficacy of current immunotherapeutic approaches against cancer.
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