期刊
ONCOIMMUNOLOGY
卷 2, 期 11, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.26512
关键词
CD8(+) T cells; CD40L; dendritic cells; IL-12; melanoma; vaccines
Dendritic cell (DC)-based anticancer vaccines have yielded disappointing results in a multitude of clinical trials. New data suggest that the clinical efficacy of DC-based vaccines may be dependent on the paracrine production of interleukin-12 in the course of antigen presentation and the consequent development of therapeutic Type 1 CD8(+) T-cell immunity.
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