期刊
ONCOIMMUNOLOGY
卷 2, 期 9, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.25581
关键词
4-1BB; adoptive cell therapy; CD137; co-stimulation; melanoma; tumor-infiltrating lymphocytes
资金
- NCI NIH HHS [P30 CA076292] Funding Source: Medline
Co-stimulation through members of the tumor necrosis factor receptor (TNFR) family appears to be critical for the generation of T cells with optimal effector-memory properties for adoptive cell therapy. Our work suggests that continuous 4-1BB/CD137 co-stimulation is required for the expansion of T cells with an optimal therapeutic profile and that the administration of 4-1BB agonists upon adoptive cell transfer further improves antitumor T-cell functions.
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