Humanizing mice for the identification of novel anticancer lipids targeting iNKT cells

the CD1d-dependent presentation of lipid antigens to natural killer T (NKT) cells is an integral part of the innate immune system. however, the development of anticancer therapies based on NKT-cell agonists has had limited success so far. humanizing mice with respect to the CD1d/NKT antigen presentation system will provide a tool to identify novel lipids that exert antineoplastic functions by targeting NKT cells before the initiation of costly and lengthy clinical trials.