期刊
ONCOIMMUNOLOGY
卷 2, 期 1, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.22565
关键词
exosomes; extracellular vesicles; Rab27a; tumor immunity
To understand the physiological functions of exosomes, we have recently used the inhibition of Rab27a, which prevents exosome release but also alters other secretion pathways. Our work demonstrates that the secretion of exosomes by some tumors in vivo can influence the immune microenvironment to promote tumor progression, but also that this phenomenon cannot be generalized to all tumors and all exosomes.
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