期刊
ONCOIMMUNOLOGY
卷 2, 期 2, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.22987
关键词
dendritic cells; FOXP3; gut homing; oral tolerance; retinoic acid
The systemic unresponsiveness of the immune system to orally administered antigens is known as oral tolerance. Recent findings describe a new step for the induction of oral tolerance, consisting in the homing of FOXP3(+) regulatory T cells to the small bowel and the local acquisition of full immunosuppressive capacities, a process in which retinoic acid-producing dendritic cells might play a crucial role.
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