期刊
ONCOIMMUNOLOGY
卷 2, 期 8, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.25083
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资金
- NCI NIH HHS [R01 CA140243, R01 CA109322] Funding Source: Medline
We have recently demonstrated that oncolytic vesicular stomatitis viruses can be efficiently and selectively delivered to neoplastic lesions by myeloid-derived suppressor cells (MDSCs). Importantly, the loading of viruses onto MDSCs inhibited their immunosuppressive properties and endowed them with immunostimulatory and tumoricidal functions. Our study demonstrates the potential use of MDSCs as a Trojan horse for the tumor-targeted delivery of various anticancer therapeutics.
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