期刊
ONCOIMMUNOLOGY
卷 2, 期 6, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.24461
关键词
scavenger receptor; tumor-associated macrophage; ligand; apo A-I mimetic peptide; co-culture
Tumor-associated macrophages polarize toward an M2 phenotype and express scavenger receptor A (SRA), hence promoting tumor progression. We demonstrated that SRA can be therapeutically targeted in vivo with the small peptide inhibitor 4F to prevent metastatic spread. Beyond our study, 4F is emerging as a promising anticancer agent.
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