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Involvement of STAT3 in immune evasion during lung tumorigenesis

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ONCOIMMUNOLOGY
卷 2, 期 1, 页码 -

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TAYLOR & FRANCIS INC
DOI: 10.4161/onci.22653

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antitumor immunity; lung; MHC Class I; MICA; NK cell; STAT3; tumorigenesis

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In a recent study, we have shown that STAT3 expressed by tumor cells blunts antitumor immunity during carcinogen-induced lung tumorigenesis. STAT3 inhibits the production of pro-inflammatory chemokines and MHC Class I chain-related gene A. In contrast, STAT3 promotes the expression of MHC Class I molecules. Consequently, STAT3 promotes tumor cell resistance to NK cell-mediated cytotoxicity.

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