期刊
ONCOIMMUNOLOGY
卷 2, 期 11, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.26442
关键词
adaptive immunity; immunotherapy; innate immunity; interferon gamma; interleukin-15; memory CD8(+) T cells; myeloma; NKG2D; tumor
资金
- NCI NIH HHS [R44 CA156740, R43 CA156740, R43 CA167925] Funding Source: Medline
ALT-803, an interleukin-15-based superagonist, induces memory CD8(+) T cells to proliferate, upregulate receptors involved in innate immunity, secrete interferon gamma and acquire the ability to kill malignant cells in the absence of antigenic stimulation. Thus, ALT-803 can promote the expansion and activation of memory CD8(+) T cells while converting them into innate immune effector cells that exhibit robust antineoplastic activity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据