期刊
ONCOIMMUNOLOGY
卷 1, 期 6, 页码 976-978出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.20059
关键词
autophagosome; DAMP; c-type lectin; dendritic cells; cross-presentation
It is generally believed that most tumor antigens are passively released from either health or dying tumor cells as intact soluble antigens, peptide fragments complexed with heat shock proteins (HSPs), or packaged in secretary vesicles in the form of microparticles or exosomes. The passive release of tumor antigens is generally non-inflammatory and non-immunogenic; however, results from others and our laboratories suggest that autophagy is critically involved in immunogenic cell death.
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