期刊
ONCOIMMUNOLOGY
卷 1, 期 7, 页码 1074-1083出版社
TAYLOR & FRANCIS INC
DOI: 10.4161/onci.20897
关键词
dendritic cells; exosomes; innate immunity; NK cells; TNF superfamily ligands
资金
- National Institute of Health [I-PO DE13059, RO1 DE14775, RO1 DE17150]
- University of Pittsburgh Cancer Institute
- Henry L. Hillman Foundation
- [P30CA047904]
Autocrine and paracrine cell communication can be conveyed by multiple mediators, including membrane-associate proteins, secreted proteins and exosomes. Exosomes are 30-100 nm endosome-derived vesicles consisting in cytosolic material surrounded by a lipid bilayer containing transmembrane proteins. We have previously shown that dendritic cells (DCs) express on their surface multiple TNF superfamily ligands (TNFSFLs), by which they can induce the apoptotic demise of tumor cells as well as the activation of natural killer (NK) cells. In the present study, we demonstrate that, similar to DCs, DC-derived exosomes (DCex) express on their surface TNF, FasL and TRAIL, by which they can trigger caspase activation and apoptosis in tumor cells. We also show that DCex activate NK cells and stimulate them to secrete interferon gamma(IFN gamma) upon the interaction of DCex TNF with NK-cell TNF receptors. These data demonstrate that DCex can mediate essential innate immune functions that were previously ascribed to DCs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据