The emergence of phox-ER stress induced immunogenic apoptosis

Primary induction of photo-oxidative (phox)-ER stress in cancer cells evoked immunogenic apoptosis (IA) associated with pre-apoptotic emission of calreticulin and ATP, and protective antitumor immunity. This IA subroutine involved core functions (e.g., PERK/ PI3K-based modulation of secretory trafficking) rather than private ones (caspase-8 and eIF2 alpha-phosphorylation) engaged by other IA inducers.