期刊
ONCOIMMUNOLOGY
卷 1, 期 3, 页码 379-381出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.18801
关键词
plasmacytoid dendritic cell; ovarian cancer; immune tolerance; prognosis; progression-free survival
Using two different and complementary approaches (flow cytometry and immunohistochemistry) on two independent cohorts of ovarian cancer patients, we found that accumulation of plasmacytoid dendritic cells (pDC) in tumors is associated with early relapse. This deleterious effect of tumor-associated pDC was evident when they are present in cancer epithelium but not in lymphoid aggregates.
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