期刊
ONCOIMMUNOLOGY
卷 1, 期 4, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.19404
关键词
CCR7; prognostic factor; tumor infiltrating lymphocytes; colorectal cancer
The immune interactions occurring within the tumor microenvironment have a critical role in determining the outcome of colorectal cancer patients. We carried-out an immunohistochemical analysis of tumor infiltrating T-lymphocytes expressing chemokine receptor 7 (CCR7) in a series of colorectal cancer patients enrolled in a prospective clinical trial. We demonstrated that a high tumor infiltration score of this lymphocyte subset is predictive of longer progression free survival and overall survival.
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