期刊
ONCOIMMUNOLOGY
卷 1, 期 4, 页码 -出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.19365
关键词
lymphoma; aggregates; immune escape models; transcriptome
Tumor-intrinsic immuno-resistance is a prerequisite for emergence of follicular lymphomas. Here we show that in vitro, such cells are more resistant to immune cytolysis when grown as follicle-mimicking tridimensional aggregates than when grown as cell suspensions. So in patients, this innate adaptation to tumor immunity might precede its selective pressure.
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