期刊
ONCOIMMUNOLOGY
卷 1, 期 3, 页码 404-406出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.19310
关键词
tolerance; p53; NY-ESO-1; tumor antigen; cancer vaccine; CD8 T lymphocytes; Serum antibody
Tumor antigens NY-ESO-1 and p53 both frequently induce spontaneous serum antibody in cancer patients. While NY-ESO-1-specific CD8(+) and CD4(+) circulating T-cells occur mainly in NY-ESO-1-seropositive patients, p53-specific circulating CD8(+) and CD4(+) T-cells are respectively undetectable and common in most individuals. Understanding T-cell split tolerance can help define suitable targets for immunotherapy.
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