期刊
ONCOIMMUNOLOGY
卷 1, 期 8, 页码 1420-1421出版社
LANDES BIOSCIENCE
DOI: 10.4161/onci.21120
关键词
cytotoxic T cells; Merkel cell carcinoma; Merkel cell polyomavirus; survival; tumor-infiltrating lymphocytes
资金
- Cancer Foundation Finland sr [110071, 120084] Funding Source: researchfish
An intense immune infiltrate, enriched in T cells, is associated with the presence of Merkel cell polyomavirus (MCPyV) DNA in Merkel cell carcinoma (MCC), a rare skin cancer. High tumor-infiltrating T-cell counts are associated with favorable survival regardless of the tumor MCPyV status. Hence, boosting host immune functions might constitute a new approach for the treatment of MCC.
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