期刊
MOLECULAR METABOLISM
卷 3, 期 7, 页码 717-730出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molmet.2014.07.009
关键词
Ghrelin secretion; Obesity; Roux-en-Y gastric bypass; Norepinephrine; Sympathetic nervous system; Glucose
资金
- NIDDK NIH HHS [F32 DK100085, K08 DK091511, T32 DK007307] Funding Source: Medline
The current study examined potential mechanisms for altered circulating ghrelin levels observed in diet-induced obesity (DIO) and following weight loss resulting from Roux-en-Y gastric bypass (RYGB). We hypothesized that circulating ghrelin levels were altered in obesity and after weight loss through changes in ghrelin cell responsiveness to physiological cues. We confirmed lower ghrelin levels in DIO mice and demonstrated elevated ghrelin levels in mice 6 weeks post-RYGB. In both DIO and RYGB settings, these changes in ghrelin levels were associated with altered ghrelin cell responsiveness to two key physiological modulators of ghrelin secretion glucose and norepinephrine. In DIO mice, increases in ghrelin cell density within both the stomach and duodenum and in somatostatin-immunoreactive D cell density in the duodenum were observed. Our findings provide new insights into the regulation of ghrelin secretion and its relation to circulating ghrelin within the contexts of obesity and weight loss. (C) 2014 The Authors. Published by Elsevier GmbH. This is an open access article under the CC BY-NC-ND license (http.creativecommons.org/licenses/by-nc-nd/3.0/).
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