期刊
MOLECULAR METABOLISM
卷 1, 期 1-2, 页码 21-31出版社
ELSEVIER
DOI: 10.1016/j.molmet.2012.07.002
关键词
Microbiome; Microbiota; Obesity; Type 2 diabetes; Non-alcoholic fatty liver disease; Innate immunity; Segmented filamentous bacteria
资金
- NIAID NIH HHS [R01 AI075159] Funding Source: Medline
- NICHD NIH HHS [T32 HD007463] Funding Source: Medline
- NIGMS NIH HHS [T32 GM063483] Funding Source: Medline
The gut microbiome has been proposed to play a causal role in obesity. Here, we review the historical context for this hypothesis, highlight recent key findings, and critically discuss issues central to further progress in the field, including the central epistemological problem for the field: how to define causality in the relationship between microbiota and obesity phenotypes. Definition of such will be critical for the field to move forward. (C) 2012 Elsevier GmbH. Open access under CC-BY-NC-ND license.
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