期刊
METHODS AND APPLICATIONS IN FLUORESCENCE
卷 2, 期 1, 页码 -出版社
IOP PUBLISHING LTD
DOI: 10.1088/2050-6120/2/1/015002
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资金
- Biotechnology and Biological Sciences Research Council [BB/K013416/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/D062861/1] Funding Source: researchfish
- BBSRC [BB/K013416/1] Funding Source: UKRI
- EPSRC [EP/D062861/1] Funding Source: UKRI
We have demonstrated energy transfer between a biological labelling dye (Alexa Fluor 405) and gold nanorods experimentally and theoretically. The fluorescence lifetime imaging microscopy and density matrix method are used to study a hybrid system of dye and nanorods under one- and two-photon excitations. Energy transfer between dye and nanorods via the dipole-dipole interaction is found to cause a decrease in the fluorescence lifetime change. Enhanced energy transfer from dye to nanorods is measured in the presence of an increased density of nanorods. This study has potential applications in fluorescence lifetime-based intra-cellular sensing of bio-analytes as well as nuclear targeting cancer therapy.
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