相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Impact of aging on heat shock protein expression in the substantia nigra and striatum of the female rat
A. M. Gleixner et al.
CELL AND TISSUE RESEARCH (2014)
ADAPTATION AND SENSITIZATION TO PROTEOTOXIC STRESS
Rehana K. Leak
DOSE-RESPONSE (2014)
Accumulation of modified proteins and aggregate formation in aging
Kerstin Nowotny et al.
EXPERIMENTAL GERONTOLOGY (2014)
Regulation of Apoptosis by Heat Shock Proteins
Donna Kennedy et al.
IUBMB LIFE (2014)
Proteostasis and the Aging Proteome in Health and Disease
Richard I. Morimoto et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)
NIH to balance sex in cell and animal studies
Janine A. Clayton et al.
NATURE (2014)
N-Acetyl cysteine prevents synergistic, severe toxicity from two hits of oxidative stress
Ajay S. Unnithan et al.
NEUROSCIENCE LETTERS (2014)
Astrocyte plasticity revealed by adaptations to severe proteotoxic stress
Amanda M. Titler et al.
CELL AND TISSUE RESEARCH (2013)
Overexpression of Hsp27 ameliorates symptoms of Alzheimer's disease in APP/PS1 mice
Melinda Erzsebet Toth et al.
CELL STRESS & CHAPERONES (2013)
Biphasic dose responses in biology, toxicology and medicine: Accounting for their generalizability and quantitative features
Edward J. Calabrese
ENVIRONMENTAL POLLUTION (2013)
Oxidative stress, neurodegeneration, and the balance of protein degradation and protein synthesis
Kalavathi Dasuri et al.
FREE RADICAL BIOLOGY AND MEDICINE (2013)
Hsp90 Inhibits α-Synuclein Aggregation by Interacting with Soluble Oligomers
Soumya Daturpalli et al.
JOURNAL OF MOLECULAR BIOLOGY (2013)
Neocortex and Allocortex Respond Differentially to Cellular Stress In Vitro and Aging In Vivo
Jessica M. Posimo et al.
PLOS ONE (2013)
Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
Meijuan Zhang et al.
PROGRESS IN NEUROBIOLOGY (2013)
Stress responses, vitagenes and hormesis as critical determinants in aging and longevity: Mitochondria as a chi
Carolin Cornelius et al.
IMMUNITY & AGEING (2013)
The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
Iakov N. Rudenko et al.
BIOCHEMICAL JOURNAL (2012)
Cellular stress responses, hormetic phytochemicals and vitagenes in aging and longevity
Vittorio Calabrese et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2012)
Haem oxygenase-I: non-canonical roles in physiology and pathology
Anna Grochot-Przeczek et al.
CLINICAL SCIENCE (2012)
Molecular Chaperones as Rational Drug Targets for Parkinsons Disease Therapeutics
S. K. Kalia et al.
CNS & Neurological Disorders-Drug Targets (2012)
Enhanced J-protein interaction and compromised protein stability of mtHsp70 variants lead to mitochondrial dysfunction in Parkinsons disease
Arvind Vittal Goswami et al.
HUMAN MOLECULAR GENETICS (2012)
Small heat shock proteins HSP27 (HspB1), αB-crystallin (HspB5) and HSP22 (HspB8) as regulators of cell death
Julie Acunzo et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2012)
Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
Kelvin C. Luk et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Antibody-Aided Clearance of Extracellular α-Synuclein Prevents Cell-to-Cell Aggregate Transmission
Eun-Jin Bae et al.
JOURNAL OF NEUROSCIENCE (2012)
Endoplasmic Reticulum Enrollment in Alzheimer's Disease
Ricardo J. S. Viana et al.
MOLECULAR NEUROBIOLOGY (2012)
A molecular signature in blood identifies early Parkinson's disease
Leonid Molochnikov et al.
MOLECULAR NEURODEGENERATION (2012)
Glucose Regulated Protein 78 Diminishes α-Synuclein Neurotoxicity in a Rat Model of Parkinson Disease
Marina S. Gorbatyuk et al.
MOLECULAR THERAPY (2012)
Rescue from a two hit, high-throughput model of neurodegeneration with N-acetyl cysteine
Ajay S. Unnithan et al.
NEUROCHEMISTRY INTERNATIONAL (2012)
The HSPB8-BAG3 chaperone complex is upregulated in astrocytes in the human brain affected by protein aggregation diseases
K. Seidel et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2012)
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
Kelvin C. Luk et al.
SCIENCE (2012)
Neurotoxicity of Amyloid β-Protein: Synaptic and Network Dysfunction
Lennart Mucke et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2012)
The Mitochondrial Chaperone Protein TRAP1 Mitigates α-Synuclein Toxicity
Erin K. Butler et al.
PLOS GENETICS (2012)
Protein homeostasis and aging: The importance of exquisite quality control
Hiroshi Koga et al.
AGEING RESEARCH REVIEWS (2011)
A Central Role of Heme Oxygenase-1 in Cardiovascular Protection
Meng-Ling Wu et al.
ANTIOXIDANTS & REDOX SIGNALING (2011)
Chaperone-mediated autophagy in protein quality control
Esperanza Arias et al.
CURRENT OPINION IN CELL BIOLOGY (2011)
Heat shock protein 90 and its cochaperone, p23, are markedly increased in the aged gerbil hippocampus
Choong Hyun Lee et al.
EXPERIMENTAL GERONTOLOGY (2011)
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells
Christian Hansen et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Heme oxygenase-1 in Alzheimer disease: a tribute to Moussa Youdim
Hyman M. Schipper
JOURNAL OF NEURAL TRANSMISSION (2011)
Hormesis, cellular stress response and vitagenes as critical determinants in aging and longevity
Vittorio Calabrese et al.
MOLECULAR ASPECTS OF MEDICINE (2011)
Higher levels of heat shock proteins in longer-lived mammals and birds
Kurtis D. Salway et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2011)
Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson's Disease Brains
Rajeswara Babu Mythri et al.
NEUROCHEMICAL RESEARCH (2011)
Protective Role of Heat Shock Proteins in Parkinson's Disease
Paolo Aridon et al.
NEURODEGENERATIVE DISEASES (2011)
Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
Laura A. Volpicelli-Daley et al.
NEURON (2011)
Ubiquitinylation of α-Synuclein by Carboxyl Terminus Hsp70-Interacting Protein (CHIP) Is Regulated by Bcl-2-Associated Athanogene 5 (BAG5)
Lorraine V. Kalia et al.
PLOS ONE (2011)
The hormesis database: The occurrence of hormetic dose responses in the toxicological literature
Edward J. Calabrese et al.
REGULATORY TOXICOLOGY AND PHARMACOLOGY (2011)
Gene-environment interactions: Key to unraveling the mystery of Parkinson's disease
Hui-Ming Gao et al.
PROGRESS IN NEUROBIOLOGY (2011)
Hsp90 regulates tau pathology through co-chaperone complexes in Alzheimer's disease
Antero Salminen et al.
PROGRESS IN NEUROBIOLOGY (2011)
Age and Energy Intake Interact to Modify Cell Stress Pathways and Stroke Outcome
Thiruma V. Arumugam et al.
ANNALS OF NEUROLOGY (2010)
Cellular Stress Responses, The Hormesis Paradigm, and Vitagenes: Novel Targets for Therapeutic Intervention in Neurodegenerative Disorders
Vittorio Calabrese et al.
ANTIOXIDANTS & REDOX SIGNALING (2010)
Chaperone-Mediated Autophagy Markers in Parkinson Disease Brains
Lydia Alvarez-Erviti et al.
ARCHIVES OF NEUROLOGY (2010)
Protein levels of heat shock proteins 27, 32, 60, 70, 90 and thioredoxin-1 in amnestic mild cognitive impairment: An investigation on the role of cellular stress response in the progression of Alzheimer disease
Fabio Di Domenico et al.
BRAIN RESEARCH (2010)
Autophagy in the Central Nervous System: Implications for Neurodegenerative Disorders
Maria Xilouri et al.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2010)
Targeting Heme Oxygenase-1 for Neuroprotection and Neuroinflammation in Neurodegenerative Diseases
Agnieszka Jazwa et al.
CURRENT DRUG TARGETS (2010)
Astrocyte heterogeneity: an underappreciated topic in neurobiology
Ye Zhang et al.
CURRENT OPINION IN NEUROBIOLOGY (2010)
Induction of the unfolded protein response and cell death pathway in Alzheimer's disease, but not in aged Tg2576 mice
Jin Hwan Lee et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2010)
Hormesis is central to toxicology, pharmacology and risk assessment
Edward J. Calabrese
HUMAN & EXPERIMENTAL TOXICOLOGY (2010)
Dissecting the role of the mitochondrial chaperone mortalin in Parkinson's disease: functional impact of disease-related variants on mitochondrial homeostasis
Lena F. Burbulla et al.
HUMAN MOLECULAR GENETICS (2010)
Hsc70 Rapidly Engages Tau after Microtubule Destabilization
Umesh K. Jinwal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
He-Jin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Are synucleinopathies prion-like disorders?
Elodie Angot et al.
LANCET NEUROLOGY (2010)
Ageing enhances α-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians
Phalguni Anand Alladi et al.
NEUROCHEMISTRY INTERNATIONAL (2010)
Age-related changes in HSP25 expression in basal ganglia and cortex of F344/BN rats
Anisha A. Gupte et al.
NEUROSCIENCE LETTERS (2010)
A dual-hit animal model for age-related parkinsonism
Heather A. Boger et al.
PROGRESS IN NEUROBIOLOGY (2010)
Chaperone-mediated autophagy: Molecular mechanisms and physiological relevance
Samantha J. Orenstein et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2010)
Heat Shock Proteins: Cell Protection through Protein Triage
David Lanneau et al.
THESCIENTIFICWORLDJOURNAL (2010)
Integration of Clearance Mechanisms: The Proteasome and Autophagy
Esther Wong et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2010)
Aging Analysis Reveals Slowed Tau Turnover and Enhanced Stress Response in a Mouse Model of Tauopathy
Chad Dickey et al.
AMERICAN JOURNAL OF PATHOLOGY (2009)
Plasticity of the Hsp90 chaperone machine in divergent eukaryotic organisms
Jill L. Johnson et al.
CELL STRESS & CHAPERONES (2009)
Chaperone proteostasis in Parkinson's disease: stabilization of the Hsp70/α-synuclein complex by Hip
Cintia Roodveldt et al.
EMBO JOURNAL (2009)
Intrinsic disorder in proteins associated with neurodegenerative diseases
Vladimir N. Uversky
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
Vitagenes, dietary antioxidants and neuroprotection in neurodegenerative diseases
Vittorio Calabrese et al.
FRONTIERS IN BIOSCIENCE-LANDMARK (2009)
The Molecular Chaperone Hsp90 Modulates Intermediate Steps of Amyloid Assembly of the Parkinson-related Protein α-Synuclein
S. Fabio Falsone et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Mutational screening of the mortalin gene (HSPA9) in Parkinson's disease
Lorena De Mena et al.
JOURNAL OF NEURAL TRANSMISSION (2009)
Recent advances in our understanding of neurodegeneration
Kurt A. Jellinger
JOURNAL OF NEURAL TRANSMISSION (2009)
Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement
Hyman M. Schipper et al.
JOURNAL OF NEUROCHEMISTRY (2009)
Seeding induced by α-synuclein oligomers provides evidence for spreading of α-synuclein pathology
Karin M. Danzer et al.
JOURNAL OF NEUROCHEMISTRY (2009)
DnaJB6 Is Present in the Core of Lewy Bodies and Is Highly Up-Regulated in Parkinsonian Astrocytes
P. F. Durrenberger et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2009)
NEUROSCIENCE Glia - more than just brain glue
Nicola J. Allen et al.
NATURE (2009)
Aging and dietary restriction alter proteasome biogenesis and composition in the brain and liver
Kalavathi Dasuri et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2009)
Alterations in lysosomal and proteasomal markers in Parkinson's disease: Relationship to alpha-synuclein inclusions
Yaping Chu et al.
NEUROBIOLOGY OF DISEASE (2009)
Etiopathogenesis of Parkinson Disease: A New Beginning?
Weidong Le et al.
NEUROSCIENTIST (2009)
Regulation of LRRK2 Stability by the E3 Ubiquitin Ligase CHIP
Xiaodong Ding et al.
PLOS ONE (2009)
Inclusion formation and neuronal cell death through neuron-to-neuron transmission of α-synuclein
Paula Desplats et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity
Han Seok Ko et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Interactions between Hsp70 and the Hydrophobic Core of α-Synuclein Inhibit Fibril Assembly
Kelvin C. Luk et al.
BIOCHEMISTRY (2008)
hsp70 genes in the human genome:: Conservation and differentiation patterns predict a wide array of overlapping and specialized functions
Luciano Brocchieri et al.
BMC EVOLUTIONARY BIOLOGY (2008)
Multiple Hsp70 isoforms in the eukaryotic cytosol: Mere redundancy or functional specificity?
Mehdi Kabani et al.
CURRENT GENOMICS (2008)
Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging
Richard I. Morimoto
GENES & DEVELOPMENT (2008)
CHIP targets toxic α-synuclein oligomers for degradation
Julie E. Tetzlaff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Heat shock proteins: essential proteins for apoptosis regulation
D. Lanneau et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2008)
Tat-Hsp70 protects dopaminergic neurons in midbrain cultures and in the substantia nigra in models of Parkinson's disease
Florian Nagel et al.
JOURNAL OF NEUROCHEMISTRY (2008)
Heat shock protein 90 modulates LRRK2 stability: Potential implications for Parkinson's disease treatment
Andres Hurtado-Lorenzo et al.
JOURNAL OF NEUROSCIENCE (2008)
Aging impairs the unfolded protein response to sleep deprivation and leads to proapoptotic signaling
Nirinjini Naidoo et al.
JOURNAL OF NEUROSCIENCE (2008)
The chaperone activity of heat shock protein 90 is critical for maintaining the stability of leucine-rich repeat kinase 2
Lizhen Wang et al.
JOURNAL OF NEUROSCIENCE (2008)
CHIP deficiency decreases longevity, with accelerated aging phenotypes accompanied by altered protein quality control
Jin-Na Min et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Physiological significance of reactive cysteine residues of keap1 in determining Nrf2 activity
Tae Yamamoto et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
HSP70 and constitutively active HSF1 mediate protection against CDCrel-1-mediated toxicity
Alisha E. Jung et al.
MOLECULAR THERAPY (2008)
Neuropathological aspects of Alzheimer disease, Parkinson disease and frontotemporal dementia
Kurt A. Jellinger
NEURODEGENERATIVE DISEASES (2008)
Response of the myocardium to exercise: Sex-specific regulation of Hsp70
Kevin J. Milne et al.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE (2008)
The Mystery and Magic of Glia: A Perspective on Their Roles in Health and Disease
Ben A. Barres
NEURON (2008)
HSPA5 promoter polymorphisms and risk of Parkinson's disease in Taiwan
Chiung-Mei Chen et al.
NEUROSCIENCE LETTERS (2008)
Increased plasma levels of heat shock protein 70 in patients with vascular mild cognitive impairment
Kang Soo Lee et al.
NEUROSCIENCE LETTERS (2008)
Autophagy and aging: keeping that old broom working
Ana Maria Cuervo
TRENDS IN GENETICS (2008)
BAG-1 associates with Hsc70•Tau complex and regulates the proteasomal degradation of Tau protein
Evan Elliott et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mitochondrial and cellular heme-dependent proteins as targets for the bioactive function of the heme oxygenase/carbon monoxide system
Mathieu Desmard et al.
ANTIOXIDANTS & REDOX SIGNALING (2007)
The heat shock protein 70 family:: Highly homologous proteins with overlapping and distinct functions
Mads Daugaard et al.
FEBS LETTERS (2007)
Basal and infection-induced levels of heat shock proteins in human aging
Rose Njemini et al.
BIOGERONTOLOGY (2007)
Multiple hit hypotheses for dopamine neuron loss in Parkinson's disease
David Sulzer
TRENDS IN NEUROSCIENCES (2007)
Reduced eIF2α phosphorylation and increased proapoptotic proteins in aging
Syed G. Hussain et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
CHIP and HSPs interact with β-APP in a proteasome-dependent manner and influence Aβ metabolism
Pravir Kumar et al.
HUMAN MOLECULAR GENETICS (2007)
Proteomic identification of novel proteins in cortical Lewy bodies
James B. Leverenz et al.
BRAIN PATHOLOGY (2007)
Accumulation of Hsc70 and Hsp70 in glial cytoplasmic inclusions in patients with multiple system atrophy
Yasuhiro Kawamoto et al.
BRAIN RESEARCH (2007)
Elevated levels of inducible heat shock 70 proteins in human brain
S. Pardue et al.
NEUROBIOLOGY OF AGING (2007)
Functions of the proteasome: from protein degradation and immune surveillance to cancer therapy
A. L. Goldberg
BIOCHEMICAL SOCIETY TRANSACTIONS (2007)
Molecular markers of early Parkinson's disease based on gene expression in blood
Clemens R. Scherzer et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Oxidative inactivation of the proteasome in Alzheimer's disease
Valentina Cecarini et al.
FREE RADICAL RESEARCH (2007)
A beta Oligomers - a decade of discovery
Dominic M. Walsh et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Neuronal expression of constitutive heat shock proteins: implications for neurodegenerative diseases
Sheng Chen et al.
CELL STRESS & CHAPERONES (2007)
Model fusion: The next phase in developing animal models for Parkinson's disease
Amy B. Manning-Bog et al.
NEUROTOXICITY RESEARCH (2007)
Alzheimer disease, the two-hit hypothesis: An update
Xiongwei Zhu et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2007)
Small heat shock proteins protect against α-synuclein-induced toxicity and aggregation
Tiago Fleming Outeiro et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Heat shock proteins 70 and 90 inhibit early stages of amyloid β-(1-42) aggregation in vitro
Christopher G. Evans et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Brain site-specific gene expression analysis in Alzheimer's disease patients
T. Yokota et al.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2006)
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a Tethering mechanism - A two-site interaction model for the Nrf2-Keap1 complex
Michael McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Protein degradation by the ubiquitin-proteasome pathway in normal and disease states
Stewart H. Lecker et al.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2006)
Proteomic identification of a stress protein, mortalin/mthsp70/GRP75 - Relevance to Parkinson disease
Jinghua Jin et al.
MOLECULAR & CELLULAR PROTEOMICS (2006)
Cellular environment facilitates protein accumulation in aged rat hippocampus
M. Paz Gavilan et al.
NEUROBIOLOGY OF AGING (2006)
Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains
MMM Wilhelmus et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2006)
Convergence of heat shock protein 90 with ubiquitin in filamentous α-synuclein inclusions of α-synucleinopathies
K Uryu et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
HM Schipper et al.
NEUROBIOLOGY OF AGING (2006)
Proteasome regulation of oxidative stress in aging and age-related diseases of the CNS
QX Ding et al.
ANTIOXIDANTS & REDOX SIGNALING (2006)
Progressive dopamine neuron loss in Parkinson's disease: The multiple hit hypothesis
Paul M. Carvey et al.
CELL TRANSPLANTATION (2006)
Autophagy and aging -: The importance of maintaining clean cells
Ana Maria Cuervo et al.
AUTOPHAGY (2005)
Transcriptional analysis of multiple brain regions in Parkinson's disease supports the involvement of specific protein processing, energy metabolism, and signaling pathways, and suggests novel disease mechanisms
YL Zhang et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2005)
The unfolded protein response is activated in Alzheimer's disease
JJM Hoozemans et al.
ACTA NEUROPATHOLOGICA (2005)
The co-chaperone carboxyl terminus of Hsp70-interacting protein (CHIP) mediates α-synuclein degradation decisions between proteasomal and lysosomal pathways
YG Shin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Expression profiling of substantia nigra in Parkinson disease, progressive supranuclear palsy, and frontotemporal dementia with parkinsonism
MA Hauser et al.
ARCHIVES OF NEUROLOGY (2005)
Hsp70 chaperones: Cellular functions and molecular mechanism
MP Mayer et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
ER stress and the unfolded protein response
M Schröder et al.
MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS (2005)
Modulation of neurodegeneration by molecular chaperones
PJ Muchowski et al.
NATURE REVIEWS NEUROSCIENCE (2005)
HsD70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease
ZZ Dong et al.
MOLECULAR THERAPY (2005)
Increased expression of heat shock proteins in rat brain during aging: relationship with mitochondrial function and glutathione redox state
V Calabrese et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Heat shock protein 70 participates in the neuroprotective response to intracellularly expressed β-amyloid in neurons
J Magrané et al.
JOURNAL OF NEUROSCIENCE (2004)
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
H Shimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Induction of neuronal death by ER stress in Alzheimer's disease
T Katayama et al.
JOURNAL OF CHEMICAL NEUROANATOMY (2004)
Pathophysiology of chaperone-mediated autophagy
A Massey et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Autophagy, proteasomes, lipofuscin, and oxidative stress in the aging brain
JN Keller et al.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Cooperation of molecular chaperones with the ubiquitin/proteasome system
C Esser et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Expression of the small heat-shock protein alpha B-crystallin in tauopathies with glial pathology
DV Dabir et al.
AMERICAN JOURNAL OF PATHOLOGY (2004)
Gene regulation and DNA damage in the ageing human brain
T Lu et al.
NATURE (2004)
Hsp70 reduces α-synuclein aggregation and toxicity
J Klucken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Protein degradation and protection against misfolded or damaged proteins
AL Goldberg
NATURE (2003)
The caspase-like sites of proteasomes, their substrate specificity, new inhibitors and substrates, and allosteric interactions with the trypsin-like sites
AF Kisselev et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Adult mouse astrocytes degrade amyloid-β in vitro and in situ
T Wyss-Coray et al.
NATURE MEDICINE (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Chaperones increase association of tau protein with microtubules
F Dou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Heat shock protein Hsp72 is a negative regulator of apoptosis signal-regulating kinase 1
HS Park et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
TorsinA and heat shock proteins act as molecular chaperones:: suppression of α-synuclein aggregation
PJ McLean et al.
JOURNAL OF NEUROCHEMISTRY (2002)
HsP70 in the inferior colliculus of Fischer-344 rats: effects of age and acoustic stress
RH Helfert et al.
HEARING RESEARCH (2002)
Apoptosis-inducing factor (AIF):: a novel caspase-independent death effector released from mitochondria
C Candé et al.
BIOCHIMIE (2002)
Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
PK Auluck et al.
SCIENCE (2002)
Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the 'two hit' hypothesis
XW Zhu et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2001)
CHIP is a U-box-dependent E3 ubiquitin ligase -: Identification of Hsc70 as a target for ubiquitylation
JH Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Heat-shock protein 70 antagonizes apoptosis-inducing factor
L Ravagnan et al.
NATURE CELL BIOLOGY (2001)
Expression of stress proteins alpha B-crystallin, ubiquitin, and hsp27 in pallido-nigral spheroids of aged rhesus monkeys
C Schultz et al.
NEUROBIOLOGY OF AGING (2001)
Regional distribution of Hsp70 in the CNS of young and old food-restricted rats following hyperthermia
TJ Walters et al.
BRAIN RESEARCH BULLETIN (2001)
The unfolded protein response and Alzheimer's disease
K Imaizumi et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2001)
Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase
HS Park et al.
EMBO JOURNAL (2001)
Cellular defenses against unfolded proteins: A cell biologist thinks about neurodegenerative diseases
MY Sherman et al.
NEURON (2001)
Upregulation of BiP and CHOP by the unfolded-protein response is independent of presenilin expression
N Sato et al.
NATURE CELL BIOLOGY (2000)
Hsp72-mediated suppression of c-Jun N-terminal kinase is implicated in development of tolerance to caspase-independent cell death
VL Gabai et al.
MOLECULAR AND CELLULAR BIOLOGY (2000)
Negative regulation of the Apaf-1 apoptosome by Hsp70
A Saleh et al.
NATURE CELL BIOLOGY (2000)
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
HM Beere et al.
NATURE CELL BIOLOGY (2000)
Increase in basal level of Hsp70, consisting chiefly of constitutively expressed Hsp70 (Hsc70) in aged rat brain
K Unno et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2000)
Gene-expression profile of the ageing brain in mice
CK Lee et al.
NATURE GENETICS (2000)
Structure of TPR domain-peptide complexes: Critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine
C Scheufler et al.
CELL (2000)
Possible involvement of proteasome inhibition in aging: implications for oxidative stress
JN Keller et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2000)
The Heme synthesis and degradation pathways: role in oxidant sensitivity - Heme oxygenase has both pro- and antioxidant properties
SW Ryter et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Molecular chaperones and the aging process
C Soti et al.
BIOGERONTOLOGY (2000)
Heme oxygenase-1: role in brain aging and neurodegeneration
HM Schipper
EXPERIMENTAL GERONTOLOGY (2000)
Decreased levels of proteasome activity and proteasome expression in aging spinal cord
JN Keller et al.
NEUROSCIENCE (2000)