期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
卷 1, 期 3, 页码 258-263出版社
ELSEVIER
DOI: 10.1016/j.jaip.2013.02.002
关键词
Adverse reaction; Allergy; Antibiotic; Amoxicillin; Oral challenge; Multiple drug intolerance syndrome; Penicillin; Skin test; Penicilloyl-poly-lysine
资金
- Kaiser Permanente Health Care Program
BACKGROUND: Penicillin skin testing is rarely used to undiagnose penicillin allergy in the United States, partially because of concern that commercially available materials are inadequate. OBJECTIVE: We determined whether skin testing with only commercially available penicilloyl-poly-lysine and penicillin followed by an oral amoxicillin challenge, if skin test-negative, can safely identify clinically significant penicillin allergy. METHODS: Five hundred sequential persons with positive history of penicillin allergy were evaluated by skin testing with penicilloyl-poly-lysine and penicillin between June 8, 2010, and March 29, 2012. All persons with negative skin tests were given an oral amoxicillin challenge and observed for 1 hour. RESULTS: Persons undergoing penicillin allergy testing were representative of all health plan members with penicillin allergy. Only 4 persons (0.8%; 95% CI, 0.32%-2.03%) had a positive skin test result. Only 4 persons (0.8%; 95% CI, 0.32%-2.03%) had an acute objective oral amoxicillin challenge reaction. Fifteen persons (3.0%; 95% CI, 1.83%-4.98%) had subjective oral challenge reactions, either acute transient itching or dizziness. All were women and 11 (73.3%) had multiple drug intolerance syndrome. None had severe reactions or objective signs. These were not considered to be positive challenge reactions. Sixty-eight subjects (13.6%) who were negative on testing were exposed to 88 courses of penicillins during 90 days of follow-up. New reactions were reported after 4 courses (4.5%), 3 (75%) occurring in subjects with multiple drug intolerance syndrome. CONCLUSIONS: Penicillin skin testing, using only penicilloyl-poly-lysine and penicillin, followed by oral amoxicillin challenge, if negative, can safely identify clinically significant IgE-mediated penicillin allergy in patients who use health care in the United States at this time. (C) 2013 American Academy of Allergy, Asthma & Immunology
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