期刊
INORGANIC CHEMISTRY FRONTIERS
卷 1, 期 5, 页码 405-413出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c3qi00086a
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资金
- Ministry of Science and Technology of Taiwan [NSC 99-2113-M-110-003-MY3, NSC 102-2113-M-110-002-MY3]
This work describes the efficacy of [PNP]PdCl (1a), where [PNP](-) = bis(2-diphenylphosphinophenyl) amide, as a catalyst precursor for C-sp-C-sp2 bond-forming cross-coupling reactions of terminal alkynes with aryl halides in the presence of copper bromide and aliphatic amines in ethereal solutions under mild conditions. This catalysis is compatible with acetylenes that are alkyl, alkenyl, (hetero) aryl, or silyl substituted and aryl iodides or bromides that are electronically activated, neutral, or deactivated. The low reaction constants of 0.82(6) and 0.97(7) obtained from Hammett plots of competitive reactions employing electronically distinct aryl iodides and terminal alkynes, respectively, are likely suggestive of irrelevance of the rate-determining step in these catalytic transformations to oxidative addition of aryl halides or generation of mono-substituted acetylides. In sharp contrast, reactions employing a phosphorus-bound isopropyl derived 1b gave rather unsatisfactory results, highlighting a profound phosphorus substituent effect on this aryl alkynylation catalysis.
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