期刊
GIGASCIENCE
卷 3, 期 -, 页码 -出版社
OXFORD UNIV PRESS
DOI: 10.1186/2047-217X-3-3
关键词
Retinal waves; Spontaneous activity; Electrophysiology; HDF5; Multielectrode arrays
资金
- EPSRC [EP/E002331/1]
- BBSRC [BB/H023577/1, BB/I000984/1]
- Wellcome Trust [083205/B/07/Z]
- Wellcome Trust [083205/B/07/Z] Funding Source: Wellcome Trust
- Biotechnology and Biological Sciences Research Council [BB/F011415/1, BB/I001042/1, BB/H023569/1, BB/H023577/1] Funding Source: researchfish
- BBSRC [BB/H023569/1, BB/H023577/1, BB/I000984/1, BB/I001042/1, BB/F011415/1] Funding Source: UKRI
Background: During early development, neural circuits fire spontaneously, generating activity episodes with complex spatiotemporal patterns. Recordings of spontaneous activity have been made in many parts of the nervous system over the last 25 years, reporting developmental changes in activity patterns and the effects of various genetic perturbations. Results: We present a curated repository of multielectrode array recordings of spontaneous activity in developing mouse and ferret retina. The data have been annotated with minimal metadata and converted into HDF5. This paper describes the structure of the data, along with examples of reproducible research using these data files. We also demonstrate how these data can be analysed in the CARMEN workflow system. This article is written as a literate programming document; all programs and data described here are freely available. Conclusions: 1. We hope this repository will lead to novel analysis of spontaneous activity recorded in different laboratories. 2. We encourage published data to be added to the repository. 3. This repository serves as an example of how multielectrode array recordings can be stored for long-term reuse.
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