期刊
FRONTIERS IN NEUROLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fneur.2014.00230
关键词
aluminum; vaccines; myofasciitis; myalgias; chronic fatigue syndrome; mild cognitive impairment; neglected diseases; CCL2
资金
- patients association: E3M (Entraide aux Malades de Myofasciite a Macrophages), Neurodelivrance des particules injectees par voie intra musculaire et securite des adjuvants aluminiques
- patients association: AFM (Association Francaise contre les Myopathies) Experimental study of neuromuscular toxicity of aluminum adsorbed vaccines [7239]
- Dwoskin Foundation
- Region Ile-de-France through PICRI (Partenariat Institutions-Citoyens pour la Recherche et l'Innovation) program Recherche de polymorphismes dans les genes codant pour des facteurs inflammatoires (chimiokines) dans la myofasciite a macrophages [241440]
Macrophagic myofasciitis (MMF) is an emerging condition characterized by specific muscle lesions assessing abnormal long-term persistence of aluminum hydroxide within macrophages at the site of previous immunization. Affected patients usually are middle-aged adults, mainly presenting with diffuse arthromyalgias, chronic fatigue, and marked cognitive deficits, not related to pain, fatigue, or depression. Clinical features usually correspond to that observed in chronic fatigue syndrome/myalgic encephalomyelitis. Representative features of MMF-associated cognitive dysfunction include dysexecutive syndrome, visual memory impairment, and left ear extinction at dichotic listening test. Most patients fulfill criteria for non-amnestic/dysexecutive mild cognitive impairment, even if some cognitive deficits appear unusually severe. Cognitive dysfunction seems stable over time despite marked fluctuations. Evoked potentials may show abnormalities in keeping with central nervous system involvement, with a neurophysiological pattern suggestive of demyelination. Brain perfusion SPECT shows a pattern of diffuse cortical and subcortical abnormalities, with hypoperfusions correlating with cognitive deficiencies. The combination of musculoskeletal pain, chronic fatigue, and cognitive disturbance generates chronic disability with possible social exclusion. Classical therapeutic approaches are usually unsatisfactory making patient care difficult.
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