期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01778
关键词
Mycobacterium tuberculosis; vitamin B1; macrophages; peroxisome proliferator; activated receptor-gamma; adjuvant
类别
资金
- National Science and Technology Major Project [2017ZX10201301-008]
- National Natural Science Foundation of China [81772150, 81571951, 81641062]
- Guangdong Natural Science Foundation [2016A030311001, 2017A030310268]
- Science and Technology Project of Guangdong Province [2017A020212007]
- Science and Technology Project of Guangzhou [201707010215]
- Medical Scientific Research Foundation of Guangdong Province [A2017073]
It is known that vitamin B1 (VB1) has a protective effect against oxidative retinal damage induced by anti-tuberculosis drugs. However, it remains unclear whether VB1 regulates immune responses during Mycobacterium tuberculosis (MTB) infection. We report here that VB1 promotes the protective immune response to limit the survival of MTB within macrophages and in vivo through regulation of peroxisome proliferator-activated receptor gamma (PPAR-gamma). VB1 promotes macrophage polarization into classically activated phenotypes with strong microbicidal activity and enhanced tumor necrosis factor-alpha and interleukin-6 expression at least in part by promoting nuclear factor-kappa B signaling. In addition, VB1 increases mitochondrial respiration and lipid metabolism and PPAR-gamma integrates the metabolic and inflammatory signals regulated by VB1. Using both PPAR-gamma agonists and deficient mice, we demonstrate that VB1 enhances anti-MTB activities in macrophages and in vivo by down-regulating PPAR-gamma activity. Our data demonstrate important functions of VB1 in regulating innate immune responses against MTB and reveal novel mechanisms by which VB1 exerts its function in macrophages.
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