期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.02169
关键词
dendritic cell; Tfh cell; DC subset; DC migration; humoral response; vaccine
类别
资金
- [R01 AI108829]
- [CTSA UL1 TR001863]
- [R21 AI133440]
- [R21 AI135221]
T follicular helper (Tfh) cells are a specialized subset of CD4(+) T cells that collaborate with B cells to promote and regulate humoral responses. Unlike other CD4(+) effector lineages, Tfh cells require interactions with both dendritic cells (DCs) and B cells to complete their differentiation. While numerous studies have assessed the potential of different DC subsets to support Tfh priming, the conclusions of these studies depend heavily on the model and method of immunization used. We propose that the location of different DC subsets within the lymph node (LN) and their access to antigen determine their potency in Tfh priming. Finally, we provide a three-step model that accounts for the ability of multiple DC subsets and related lineages to support the Tfh differentiation program.
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