期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01882
关键词
sperm tolerance; infertility; autoimmunity; transforming growth factor; dendritic cells
类别
资金
- NIH/NIGMS [P20 GM103418]
- K-State Johnson Cancer Research Center
- K-State College of Veterinary Medicine
- NIH [5R01 DK109711]
The epididymis exhibits a less restrictive physical blood-tissue barrier than the testis and, while numerous immunosuppressive factors have been identified in the latter, no mechanisms for epididymal immunotolerance have been identified to date. Therefore, data are currently insufficient to explain how the immune system tolerates the extremely large load of novel antigens expressed on sperm, which become present in the male body after puberty, i.e., long after central tolerance was established. This study tested the hypothesis that transforming growth factor beta (TGF beta) signaling in dendritic cells (DCs) is required for immunotolerance to sperm located in the epididymis, and that male mice lacking TGF beta signaling in DCs would develop severe epididymal inflammation. To test this, we employed adult Tgfbr2(Delta DC) males, which exhibit a significant reduction of Tgfbr2 expression and TGF beta signaling in DCs, as reported previously. Results show that Tgfbr2(Delta DC) males exhibit sperm-specific immune response and severe epididymal leukocytosis. This phenotype is consistent with epididymal loss of immunotolerance to sperm and suggests that TGF beta signaling in DCs is a factor required for a non-inflammatory steady state in the epididymis, and therefore for male tract homeostasis and function.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据