期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.01681
关键词
two-photon microscopy; intravital imaging; bone marrow microenvironment; tumor cell dormancy; cancer cell
类别
资金
- faculty research grant from Yonsei University College of Medicine [6-2016-0132]
- National Research Foundation of Korea (NRF) grant - Korean government (MSIP) [2016R1A2B4008199]
- Mid-Career Researcher Program through a National Research Foundation of Korea grant [2016R1A2B4011115]
Disseminated tumor cells in the bone marrow environment are the main cause of systemic metastasis after curative treatment for major solid tumors. However, the detailed biological processes of tumor biology in bone marrow have not been well defined in a real-time manner, because of a lack of a proper in vivo experimental model thereof. In this study, we established intravital imaging models of the bone marrow environment to enable real-time observation of cancer cells in the bone marrow. Using these novel imaging models of intact bone marrow and transplanted bone marrow of mice, respectively, via two-photon microscopy, we could first successfully track and analyze both the distribution and the phenotype of cancer cells in bone marrow of live mouse. Therefore, these novel in vivo imaging models for the bone marrow would provide a valuable tool to identify the biologic processes of cancer cells in a real-time manner in a live animal model.
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