期刊
FRONTIERS IN IMMUNOLOGY
卷 5, 期 -, 页码 1-7出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00474
关键词
neonate; innate immunity; mucosal immunology; pattern recognition receptor; antimicrobial peptide; development; infection; inflammation
类别
资金
- German Research Foundation [Ho2236/8-1]
- DFG [1656, 1580]
- Niedersachsen-Research Network on Neuroinfectiology (N-RENNT)
- Collaborative Research Center [SFB900]
- Lower Saxony-Israel Found
- Center for Infection Biology (ZIB)
- international research training group within Hannover Biomedical Research School (HBRS) [IRTG1273]
Emerging evidence indicates that processes during postnatal development might significantly influence the establishment of mucosal host-microbial homeostasis. Developmental and adaptive immunological processes but also environmental and microbial exposure early after birth might thus affect disease susceptibility and health during adult life. The present review aims at summarizing the current understanding of the intestinal epithelial innate immune system and its developmental and adaptive changes after birth.
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