期刊
FRONTIERS IN IMMUNOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00022
关键词
IMGT; immunogenetics; immunoinformatics; IMGT-ONTOLOGY; IMGT Collier de Perles; immunoglobulin; T cell receptor; major histocompatibility
类别
资金
- BIOMED1 [BIOCT930038]
- Biotechnology BIOTECH2 [BIO4CT960037]
- Fifth PCRDT Quality of Life and Management of Living Resources [QLG2-2000-01287]
- Sixth PCRDT Information Science and Technology (ImmunoGrid) programs of the European Union (EU) [FP6 IST-028069]
- Centre National de la Recherche Scientifique (CNRS)
- Ministere de l'Enseignement Superieur et de la Recherche (MESR)
- University Montpellier 2
- Agence Nationale de la Recherche (ANR) Labex MabImprove [ANR-10-LABX-53-01]
- BioCampus Montpellier
- Region Languedoc-Roussillon (Grand Plateau Technique pour la Recherche (GPTR)
IMGT (R), the international ImMunoGeneTics information system (R) 1, (CNRS and Universite Montpellier 2) is the global reference in immunogenetics and immunoinformatics. By its creation in 1989, IMGT (R) marked the advent of immunoinformatics, which emerged at the interface between immunogenetics and bioinformatics. IMGT (R) is specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility (MH), and proteins of the IgSF and MhSF superfamilies. IMGT (R) has been built on the IMGTONTOLOGY axioms and concepts, which bridged the gap between genes, sequences, and three-dimensional (3D) structures.The concepts include the IMGT (R) standardized keywords (concepts of identification), IMGT (R) standardized labels (concepts of description), IMGT (R) standardized nomenclature (concepts of classification), IMGT (R) unique numbering, and IMGT (R) Colliers de Perles (concepts of numerotation). IMGT (R) comprises seven databases, 15,000 pages of web resources, and 17 tools, and provides a high-quality and integrated system for the analysis of the genomic and expressed IG and TR repertoire of the adaptive immune responses. Tools and databases are used in basic, veterinary, and medical research, in clinical applications (mutation analysis in leukemia and lymphoma) and in antibody engineering and humanization. They include, for example IMGT/V-QUEST and IMGT/JunctionAnalysis for nucleotide sequence analysis and their high-throughput version IMGT/HighV-QUEST for next-generation sequencing (500,000 sequences per batch), IMGT/DomainGapAlign for amino acid sequence analysis of IG and TR variable and constant domains and of MH groove domains, IMGT/3Dstructure-DB for 3D structures, contact analysis and paratope/epitope interactions of IG/antigen and TR/peptide-MH complexes and IMGT/mAb-DB interface for therapeutic antibodies and fusion proteins for immune applications (FPIA).
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