期刊
FRONTIERS IN IMMUNOLOGY
卷 5, 期 -, 页码 1-6出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00490
关键词
atherosclerosis; hematopoiesis; cholesterol efflux; monocytes; macrophages; HDL
类别
资金
- Diabetes Australia Research Trust Australia
- National Health and Medical Research Council program grant [APP10363652]
- Australian Postgraduate Award
- NIH [HL107653]
Atherosclerotic cardiovascular disease is a chronic inflammatory disease of the blood vessels that can lead to myocardial infarction or stroke. The major cell in the atherosclerotic lesion, the macrophage, is thought to be an important contributor to the production of inflammatory mediators that exacerbate this disease. Macrophages are generally derived from circulating monocytes, which are in turn produced by hematopoietic stem and multipotential progenitor cells (HSPCs) in the bone marrow and other medullary organs. Recent studies suggest that disruption in cholesterol homeostasis or prolonged exposure to a hypercholesterolemic environment can influence HSPCs to over-produce monocytes, resulting in monocytosis. These monocytes may carry a pre-programed ability to become M1-like macrophages once they enter the atherosclerotic lesion. Future studies may help to differentiate the role of such pre-programing versus responses to local environmental cues in determining M1, M2, or other macrophage phenotypes in atherosclerotic lesions.
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