期刊
FRONTIERS IN IMMUNOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2014.00333
关键词
Foxp3; immune tolerance; immune memory; regulatoryT cells; T cell homeostasis
类别
资金
- NIH [AR064554, AR055695, AI067750, AI085130, HL098067]
- Austrian Science Fund (FWF) [J2997-B13]
- Dystrophic Epidermolysis Bullosa Research Association (DEBRA) International and DEBRA Austria
Foxp3(+) regulatory T cells (Treg cells) are essential for establishing and maintaining selftolerance, and also inhibit immune responses to innocuous environmental antigens. Imbalances and dysfunction in Treg cells lead to a variety of immune-mediated diseases, as deficits in Treg cell function contribute to the development autoimmune disease and pathological tissue damage, whereas overabundance of Treg cells can promote chronic infection and tumorigenesis. Recent studies have highlighted the fact that Treg cells themselves are a diverse collection of phenotypically and functionally specialized populations, with distinct developmental origins, antigen-specificities, tissue-tropisms, and homeostatic requirements. The signals directing the differentiation of these populations, their specificities and the mechanisms by which they combine to promote organ-specific and systemic tolerance, and how they embody the emerging property of regulatory memory are the focus of this review.
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