期刊
FRONTIERS IN IMMUNOLOGY
卷 5, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fimmu.2014.00098
关键词
B cell; immunology; immune disorder; microRNA; gene-expression regulation
类别
资金
- Medical Research Council (MRC) Centre for Transplantation, King's College London, UK - MRC [MR/J006742/1]
- National Institute for Health Research (NIHR) Biomedical Research Centre at Guy's and St Thomas' NHS Foundation Trust
- King's College London
- National Research Agency via the investment of the future program [ANR-10-IBHU-005]
- Nantes Metropole and the Pays de la Loire Region
- Fondation Centaure (RTRS)
- Medical Research Council [MR/J006742/1] Funding Source: researchfish
As a main actor in humoral immunity, B cells participate in various antibody-related disorders. However, a deeper understanding of B-cell differentiation and function is needed in order to decipher their immune-modulatory roles, notably with the recent highlighting of regulatory B cells. microRNAs (miRNAs), key factors in various biological and pathological processes, have been shown to be essential for B-cell homeostasis, and therefore understanding their participation in B-cell biology could help identify biomarkers and contribute toward curing B-cell-related immune disorders. This review aims to report studies casting light on the roles played by miRNAs in B-cell lineage and function and B-cell-related immune pathologies.
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