期刊
FRONTIERS IN IMMUNOLOGY
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2012.00101
关键词
Th2 cytokine; natural helper cell; fat-associated lymphoid cluster; nuocyte; innate helper type 2; helminth; asthma; allergic inflammation
类别
资金
- Japan Society for the Promotion of Science [22689013, 22229004]
- Precursory Research for Embryonic Science and Technology (PRESTO) from Japan Science and Technology Agency
- Grants-in-Aid for Scientific Research [22229004] Funding Source: KAKEN
Cooperation between the innate and adaptive immune responses is critical for enabling protective immunity against various invading microbes. Distinct types of effector T cells have different functions in adaptive immune responses. Th1 cells play important roles in the control of intracellular bacteria by producing IFN-gamma to activate macrophages and in anti-viral immunity by producing IFN-gamma and activating cytotoxic T lymphocytes. Th2 cell-derived cytokines are important in activating mast cells, eosinophils, and goblet cells in anti-helminth immunity. Th17 cells are pivotal for the inflammatory response mediated by neutrophils, which resists extracellular bacterial infection. In all cases, it is critical that the innate immune responses limit the growth and expansion of invading microbes until antigen-specific adaptive immune responses are established. Recent studies have identified multiple subsets in innate lymphocytes corresponding to previously defined Th subsets. Classical natural killer cells, ROR gamma(+) lymphoid tissue inducer-related cells, and Th2-type innate lymphocytes play distinct roles in innate immune responses by producing Th1, Th17, and Th2 cytokines, respectively. Cooperation between innate lymphocytes and antigen-specific T and B cells are likely important in protective immunity against distinct types of microbes. The most recently identified subset is the ROR gamma-independent Lin(-)Thy-1(+)IL-7R(+)GATA3(+) innate lymphocyte subset such as natural helper (NH) cell, which is 1d2- and 1L7-dependent. This population producesTh2 cytokines, most notably IL-5 and IL-13, and plays a major role in innate immune responses during anti-helminth immunity. In addition, these cells are likely involved in the pathophysiology of some types of allergic diseases. We summarize here current knowledge regarding various innate lymphocyte subsets. In particular, we focus on the Th2-type innate lymphocyte subset.
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