期刊
FRONTIERS IN IMMUNOLOGY
卷 3, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2012.00359
关键词
natural killer cells; mathematical modeling; systems biology; signaling pathways; activating receptors; inhibitory receptors; proliferation
类别
资金
- Israel Science Foundation [759/01, 1503/08]
- Human Frontiers Science Program - a Young Investigator Grant
- Teva Pharmaceuticals
- Deutsche Forschungsgemeinschaft [TRR83-TP16, WA 1552/2-1]
- BMBF (BioFuture grant)
- BMBF (Helmholtz-Alliance on Systems Biology, SBCancer)
- Deutsche Krebshilfe
The activity of natural killer (NK) cells is regulated by various processes including education/licensing, priming, integration of positive and negative signals through an array of activating and inhibitory receptors, and the development of memory-like functionality. These processes are often very complex due to the large number of different receptors and signaling pathways involved. Understanding these complex mechanisms is therefore a challenge, but is critical for understanding NK cell regulation. Mathematical approaches can facilitate the analysis and understanding of complex systems. Therefore, they may be instrumental for studies in NK cell biology. Here we provide a review of the different mathematical approaches to the analysis of NK cell signal integration, activation, proliferation, and the acquisition of inhibitory receptors. These studies show how mathematical methods can aid the analysis of NK cell regulation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据