期刊
FRONTIERS IN IMMUNOLOGY
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2011.00036
关键词
CD161; interleukin-17; T cells; T helper 17 cells; NK cells; NK-T cells; NKRP1
类别
资金
- Wellcome Trust [WT091663MA]
- MRC
- NIHR Biomedical Research Centre, Oxford
- James Martin School for twenty first Century, Oxford
- NIH NIAID [1U19AI082630-01]
- National Institute for Health Research [NF-SI-0510-10204] Funding Source: researchfish
Expression of the Natural Killer cell receptor CD161 has recently been identified on a subset of T cells, including both CD4+ T helper and CD8+ T cells. Expression of this molecule within the adult circulation is restricted to those T cells with a memory phenotype. However, the distinct properties of these T cell populations is yet to be fully determined, although expression of CD161 has been related to the secretion of interleukin-17, and therefore to a type 17 phenotype. Recent studies have aimed to determine both the origin of these cells and the significance of CD161 expression as either a marker of specific cell types or as an effector and regulator of lymphocyte function, and hence to characterize the role of these CD 161+ cells within a variety of human diseases in which they have been implicated.
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