期刊
FRONTIERS IN IMMUNOLOGY
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2011.00072
关键词
Src-family kinases; T cell receptor; CD8; Lck; Fyn
类别
资金
- NIH [GM065230, AI074074]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM065230] Funding Source: NIH RePORTER
Recent data with CD8+T cells show that the initial phase of T cell receptor (TCR) binding to MHC-peptide (MHCp) is quickly followed by a second, stronger, binding phase representing the binding of CD8 to the MHCp. This second phase requires signaling by a Src-family kinase such as Lck. These data point out two aspects of the initial stage of TCR signaling that have not yet been clearly resolved. Firstly, how and by which Src-family kinase, is the initial phosphorylation of CD3 zeta accomplished, given that the Lck associated with the co-receptors (CD4 or CD8) is not yet available. Secondly, what is the mechanism by which the co-receptor is brought close to the bound TCR before the co-receptor binds to MHCp?
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