期刊
EXPERT REVIEW OF RESPIRATORY MEDICINE
卷 12, 期 9, 页码 755-767出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/17476348.2018.1506331
关键词
Airway hyperreactivity; adipose tissue; pulmonary function
资金
- National Institutes of Health (NIH) [R01 HL130847]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL130847] Funding Source: NIH RePORTER
Introduction: There is a major epidemic of obesity, and many obese patients suffer with respiratory symptoms and disease. The overall impact of obesity on lung function is multifactorial, related to mechanical and inflammatory aspects of obesity.Areas covered: Obesity causes substantial changes to the mechanics of the lungs and chest wall, and these mechanical changes cause asthma and asthma-like symptoms such as dyspnea, wheeze, and airway hyperresponsiveness. Excess adiposity is also associated with increased production of inflammatory cytokines and immune cells that may also lead to disease. This article reviews the literature addressing the relationship between obesity and lung function, and studies addressing how the mechanical and inflammatory effects of obesity might lead to changes in lung mechanics and pulmonary function in obese adults and children.Expert commentary: Obesity has significant effects on respiratory function, which contribute significantly to the burden of respiratory disease. These mechanical effects are not readily quantified with conventional pulmonary function testing and measurement of body mass index. Changes in mediators produced by adipose tissue likely also contribute to altered lung function, though as of yet this is poorly understood.
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