期刊
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
卷 5, 期 2, 页码 125-136出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13346-013-0142-2
关键词
Islet; PEG; Matrix; Vascularization; Angiogenesis; Mesentery; VEGF
资金
- NIH [R01-EB004496]
- Georgia Tech/Emory Center (GTEC) for the Engineering of Living Tissues
- Atlanta Clinical and Translational Science Institute (ACTSI) by PHS Grant from the Clinical and Translational Science Award program, National Institutes of Health, National Center for Research Resources [UL1 RR025008]
- National Science Foundation under the Science and Technology Center Emergent Behaviors of Integrated Cellular Systems (EBICS) [CBET-0939511]
- AHA predoctoral fellowship
Biofunctionalized polyethylene glycol maleimide (PEG-MAL) hydrogels were engineered as a platform to deliver pancreatic islets to the small bowel mesentery and promote graft vascularization. VEGF, a potent stimulator of angiogenesis, was incorporated into the hydrogel to be released in an on-demand manner through enzymatic degradation. PEG-MAL hydrogel enabled extended in vivo release of VEGF. Isolated rat islets encapsulated in PEG-MAL hydrogels remained viable in culture and secreted insulin. Islets encapsulated in PEG-MAL matrix and transplanted to the small bowel mesentery of healthy rats grafted to the host tissue and revascularized by 4 weeks. Addition of VEGF release to the PEG-MAL matrix greatly augmented the vascularization response. These results establish PEG-MAL engineered matrices as a vascular-inductive cell delivery vehicle and warrant their further investigation as islet transplantation vehicles in diabetic animal models.
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