期刊
CURRENT OPINION IN INSECT SCIENCE
卷 6, 期 -, 页码 28-34出版社
ELSEVIER
DOI: 10.1016/j.cois.2014.09.019
关键词
-
资金
- General Secretariat for Research and Technology, Hellenic Republic Ministry of National Education and Religious Affairs, in Greece
- NCSR 'Demokritos'
An overview of recent RNAi research in Lepidoptera is presented here, with silkworm cell lines being recently proven to represent good models for analysis of the basic RNAi machinery. In animals, involvement of the miRNA and piRNA pathway in antiviral defense and transposon control, respectively, was analyzed. Both miRNA and piRNA pathways are also shown to be involved in the regulation of several physiological and developmental processes, such as sex determination. Furthermore, recent studies have focused on the search for factors that could explain the relative refractoriness of lepidopterans to systemic RNAi, while silkworm cell lines have been engineered for efficient extracellular dsRNA uptake, with biotechnological applications. Considerable optimization needs to be done for RNAi to succeed as a method for pest control, especially regarding efficient delivery of dsRNA.
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