期刊
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
卷 12, 期 2, 页码 124-127出版社
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
DOI: 10.9758/cpn.2014.12.2.124
关键词
Depression; Dexamethasone; Ketamine; NMDA receptors; Antidepressants
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [24116006]
- JSPS Invitation Fellowship Program for Research in Japan
Objective: Pediatric depression is associated with significant functional impairment at school and at work, Recently, we reported on depression-like behavior in juvenile mice neonatally exposed to dexamethasone (DEX) as a potential animal model for pediatric depression, The N-methyl-D-aspartate (NMDA) receptor antagonist ketamine has promoted rapid and long lasting antidepressant effects in patients with treatment-resistant major depression. This study was conducted to examine whether ketamine had antidepressant effects in juvenile mice after neonatal DEX exposure, Methods: A single dose (10 mg/kg) of ketamine or vehicle was injected into juvenile mice at days 29-32 after neonatal DEX (or saline) exposure (days 1-3). The sucrose preference test, tail suspension test, and forced swimming test were performed 24, 40, and 46 hours, respectively, after injection of ketamine. Results: Ketamine (10 mg/kg) significantly improved depression like behavior in DEX treated juvenile mice, Conclusion: This finding suggests that ketamine confers antidepressant effects in an animal model of pediatric depression,
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