期刊
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
卷 11, 期 2, 页码 45-52出版社
KOREAN COLL NEUROPSYCHOPHARMACOLOGY
DOI: 10.9758/cpn.2013.11.2.45
关键词
Matrix metalloproteinase; Tissue inhibitor of metalloproteinase; Epilepsy; Seizure; Nerve growth factors
资金
- Japan Society for the Promotion of Science [21790068, 22390046, 23790082, 23659135]
- Japan Epilepsy Research Foundation
- Kowa Life Science Foundation, Japan
- Nakatomi Foundation, Japan
- Smoking Research Foundation, Japan
- global COE program grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan
- Academic Frontier Project for Private Universities
- MEXT
- Grants-in-Aid for Scientific Research [23659135, 21790068, 23790082] Funding Source: KAKEN
Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy.
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