4.2 Review

The potential for selective pharmacological therapies through biased receptor signaling

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Biochemistry & Molecular Biology

A Simple Method for Quantifying Functional Selectivity and Agonist Bias

Terry Kenakin et al.

ACS CHEMICAL NEUROSCIENCE (2012)

Article Multidisciplinary Sciences

Biased Signaling Pathways in β2-Adrenergic Receptor Characterized by 19F-NMR

Jeffrey J. Liu et al.

SCIENCE (2012)

Article Pharmacology & Pharmacy

Functional Selectivity and Biased Receptor Signaling

Terry Kenakin

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2011)

Article Multidisciplinary Sciences

Crystal structure of the β2 adrenergic receptor-Gs protein complex

Soren G. F. Rasmussen et al.

NATURE (2011)

Article Pharmacology & Pharmacy

Selectively Engaging β-Arrestins at the Angiotensin II Type 1 Receptor Reduces Blood Pressure and Increases Cardiac Performance

Jonathan D. Violin et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2010)

Article Medicine, Research & Experimental

β-Arrestin1 mediates nicotinic acid-induced flushing, but not its antilipolytic effect, in mice

Robert W. Walters et al.

JOURNAL OF CLINICAL INVESTIGATION (2009)

Review Cardiac & Cardiovascular Systems

Molecular determinants of angiotensin II type 1 receptor functional selectivity

Mark Aplin et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2009)

Article Pharmacology & Pharmacy

Selectivity of Agonists for the Active State of M-1 to M-4 Muscarinic Receptor Subtypes

Katherine W. Figueroa et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)

Article Biochemistry & Molecular Biology

Gα-subunits differentially alter the conformation and agonist affinity of κ-opioid receptors

Feng Yan et al.

BIOCHEMISTRY (2008)

Article Pharmacology & Pharmacy

Kinetics of G-protein-coupled receptor signals in intact cells

M. J. Lohse et al.

BRITISH JOURNAL OF PHARMACOLOGY (2008)

Article Pharmacology & Pharmacy

Unique agonist-bound cannabinoid CB1 receptor conformations indicate agonist specificity in signaling

Teodora Georgieva et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2008)

Article Biochemistry & Molecular Biology

Membrane type 1 matrix metalloproteinase induces epithelial-to-mesenchymal transition in prostate cancer.

Jian Cao et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Multidisciplinary Sciences

Agonist-directed signaling of the serotonin 2A receptor depends on β-arrestin-2 interactions in vivo

Cullen L. Schmid et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

β-Arrestin-1 mediates glucagon-like peptide-1 signaling to insulin secretion in cultured pancreatic β cells

Noriyuki Sonoda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Multidisciplinary Sciences

A unique mechanism of β-blocker action:: Carvedilol stimulates β-arrestin signaling

James W. Wisler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Cardiac & Cardiovascular Systems

Anti-β1-adrenergic receptor autoantibodies are potent stimulators of the ERK1/2 pathway in cardiac cells

Antonio S. Tutor et al.

CARDIOVASCULAR RESEARCH (2007)

Review Pharmacology & Pharmacy

β-arrestin-biased ligands at seven-transmembrane receptors

Jonathan D. Violin et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Review Pharmacology & Pharmacy

GPCR functional selectivity has therapeutic impact

Richard B. Mailman

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Review Pharmacology & Pharmacy

Allosteric GPCR modulators: taking advantage of permissive receptor pharmacology

Katie Leach et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2007)

Article Multidisciplinary Sciences

β-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes

Keshava Rajagopal et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Chemistry, Multidisciplinary

A statistical thermodynamic model of the protein ensemble

Vincent J. Hilser et al.

CHEMICAL REVIEWS (2006)

Article Biochemistry & Molecular Biology

Molecular basis of inverse agonism in a G protein-coupled receptor

JP Vilardaga et al.

NATURE CHEMICAL BIOLOGY (2005)

Review Pharmacology & Pharmacy

Multiple signaling states of G-protein-coupled receptors

DM Perez et al.

PHARMACOLOGICAL REVIEWS (2005)

Article Biochemistry & Molecular Biology

Molecular characterization of a purified 5-HT4 receptor -: A structural basis for drug efficacy

JL Banères et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Article Endocrinology & Metabolism

Bone response to intermittent parathyroid hormone is altered in mice null for β-arrestin2

SL Ferrari et al.

ENDOCRINOLOGY (2005)

Article Pharmacology & Pharmacy

Morphine side effects in beta-arrestin 2 knockout mice

KM Raehal et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Cardiac & Cardiovascular Systems

Beta-blockers in heart failure: Are pharmacological differences clinically important?

M Metra et al.

HEART FAILURE REVIEWS (2004)

Article Biochemistry & Molecular Biology

Sequential binding of agonists to the β2 adrenoceptor -: Kinetic evidence for intermediate conformational states

G Swaminath et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Article Multidisciplinary Sciences

Independent β-arrestin 2 and G protein-mediated pathways for angiotensin II activation of extracellular signal-regulated kinases 1 and 2

HJ Wei et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Biotechnology & Applied Microbiology

Measurement of the millisecond activation switch of G protein-coupled receptors in living cells

JP Vilardaga et al.

NATURE BIOTECHNOLOGY (2003)

Article Cardiac & Cardiovascular Systems

Subtype specific roles of β-adrenergic receptors in apoptosis of adult rat ventricular myocytes

Y Shizukuda et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2002)

Article Pharmacology & Pharmacy

Functional selectivity of dopamine receptor agonists.: I.: Selective activation of postsynaptic dopamine D2 receptors linked to adenylate cyclase

DM Mottola et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2002)

Review Biochemistry & Molecular Biology

Crystal structure of rhodopsin: implications for vision and beyond

T Okada et al.

CURRENT OPINION IN STRUCTURAL BIOLOGY (2001)

Article Biochemistry & Molecular Biology

Functionally different agonists induce distinct conformations in the G protein coupling domain of the β2 adrenergic receptor

P Ghanouni et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2001)