期刊
ORGANIC CHEMISTRY FRONTIERS
卷 2, 期 8, 页码 968-972出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5qo00132c
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资金
- National Natural Science Foundation of P. R. China [21272192, 21201143, 21472154]
- Program for Changjiang Scholars and Innovative Research Team of P. R. China (PCSIRT)
- National Thousand Talents Program of P. R. China
- 985 Program of the Chemistry and Chemical Engineering disciplines of Xiamen University
An asymmetric aza-Henry reaction between isatin-derived ketimines and aryl nitromethanes is catalyzed by an inert octahedral chiral-at-metal iridium(III) complex which serves as a chiral Bronsted base. Initially, a kinetically favored diastereomer is formed with high diastereoselectivity and excellent enantioselectivity, and can be epimerized efficiently under base catalysis into the thermodynamically favored diastereomer. The work underscores the potential of our metal-templated approach for the design of high performance asymmetric catalysts.
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