期刊
APPLIED SCIENCES-BASEL
卷 3, 期 3, 页码 614-623出版社
MDPI AG
DOI: 10.3390/app3030614
关键词
aqueous synthesis; solid-phase peptide synthesis; microwave assisted synthesis; nanoparticles; Boc chemistry
类别
资金
- Strategic Research Foundation at Private Universities matching fund from the Japanese Ministry of Education, Culture, Sports Science and Technology [S1201010]
- Takeda Science Foundation
We have previously developed water-based microwave (MW)-assisted peptide synthesis using Fmoc-amino acid nanopaticles. It is an organic solvent-free, environmentally friendly method for peptide synthesis. Here we describe water-based MW-assisted solid-phase synthesis using Boc-amino acid nanoparticles. The microwave irradiation allowed rapid solid-phase reaction of nanoparticle reactants on the resin in water. We also demonstrated the syntheses of Leu-enkephalin, Tyr-Gly-Gly-Phe-Leu-OH, and difficult sequence model peptide, Val-Ala-Val-Ala-Gly-OH, using our water-based MW-assisted protocol with Boc-amino acid nanoparticles.
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